| DATUM | THUISPLOEG | UITSLAG | UITPLOEG |
| 05/09/21 15.00u | SV Belisia Bilzen | 2-0 | KVC Houtvenne |
| 11/09/21 20:00u | KVC Houtvenne | 1-4 | K.Diegem Sport |
| 18/09/21 19:30u | RC Hades Kiewit Hasselt | 1-1 | KVC Houtvenne |
| 25/09/21 20:00u | KVC Houtvenne | 1-3 | Lyra-Lierse Berlaar |
| 3/10/21 15:00u | S.K. Pepingen-Halle A | 0-2 | KVC Houtvenne |
| 9/10/21 20:00u | KVC Houtvenne | 1-1 | K.Berchem Sport 2004 A |
| 16/10/21 20:00u | Hoogstraten VV | 4-0 | KVC Houtvenne |
| 23/10/21 20:00u | KVC Houtvenne | 1-2 | K.Londerzeel SK. A |
| 31/10/21 15:00u | R.Cappellen FC | 3-1 | KVC Houtvenne |
| 06/11/21 20:00u | KVC Houtvenne | 0-3 | SP.Hasselt |
| 14/11/21 15:00u | K.Olympia SC.Wijgmaal A | 2-4 | KVC Houtvenne |
| 20/11/21 20:00u | KVC Houtvenne | 1-1 | K.Bocholter VV. A |
| 27/11/21 20:00u | KVC Houtvenne | 1-4 | SC.Eendracht Aalst |
| 4/12/21 20:00u | SC.City Pirates Antwerpen A | 3-2 | KVC Houtvenne |
| 11/12/21 20:00u | KVC Houtvenne | 0-1 | KSK.Tongeren A |
| 18/12/21 20:00u | KVC Houtvenne | 1-2 | SV Belisia Bilzen |
| 29/01/22 20:00u | Lyra-Lierse Berlaar | 0-1 | KVC Houtvenne |
| 6/02/22 15:00u | KVC Houtvenne | 1-1 | S.K. Pepingen-Halle A |
| 12/02/22 20:00u | K.Berchem Sport 2004 A | 0-0 | KVC Houtvenne |
| 19/02/22 20:00u | KVC Houtvenne | | Hoogstraten VV. |
| 27/02/22 15:00u | K. Diegem Sport | | KVC Houtvenne |
| 5/03/22 19:30u | K.Londerzeel SK. A | | KVC Houtvenne |
| 12/03/22 20:00u | KVC Houtvenne | | R.Cappellen FC. |
| 19/03/22 20:00u | SP.Hasselt | | KVC Houtvenne |
| 26/03/22 20:00u | KVC Houtvenne | | K. Olympia S.C. Wijgmaal A |
| 02/04/22 19:30u | K. Bocholter VV A | | KVC Houtvenne |
| 10/04/22 15:00u | SC Eendracht Aalst | | KVC Houtvenne |
| 17/04/22 15:00u | KVC Houtvenne | | RC Hades Hasselt |
| 24/04/22 15:00u | KVC Houtvenne | | SC City Pirates Antwerpen |
| 01/05/22 15:00u | KSK Tongeren A | | KVC Houtvenne |
